MyBioSource.com's Cytochrome P450 1A2 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry. The Cytochrome P450 1A2 Antibody was generated using CP12, and CYP1A2 as the antigen and it reacts with Human, and Mouse.
Description
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.Jaiswal A.K., Nucleic Acids Res. 14:6773-6774(1986).Corchero J., Pharmacogenetics 11:1-6(2001).Soyama A.,Drug Metab. Pharmacokinet. 20:24-33(2005)